Downstream Process Development Researcher

We are seeking a motivated downstream development and MSAT researcher to join our Biologics team. This role focuses on purification process development for monoclonal antibodies and complex biologics (e.g., bispecific antibodies), supporting downstream operations across multiple scales—from shake flasks and mini-bioreactors to 5 L, 50 L, and 200 L batches.

This position provides the opportunity to build dual expertise in Downstream PD + MSAT, contributing to process robustness, scale-up success, and transfer to manufacturing.

Downstream Process Development & Purification • Perform chromatography-based purification of mAbs and complex biologics (e.g., Protein A, IEX, HIC, SEC) • Execute purification across scales: o Shake flask & mini-bioreactor materials o 5 L & 50 L pilot batches o Up to 200 L tox material production • Optimize process performance to enhance yield, purity, and scalability

In-Process Control (IPC) & Quality Analysis • Perform IPC and product quality testing including: UV, SDS-PAGE, SEC-HPLC, HCP, HCD, and endotoxin assays • Ensure timely data turnaround for decision-making and purification control • Maintain accurate batch documentation and prepare data reports for decision making

MSAT & Scale-up Support • Support scale-up operations and manufacturability evaluation • Participate in process troubleshooting and continuous improvement